Dr Hamish Wallace
Reader.
Telephone: 0131 536 0425 (20425). Email: Hamish.Wallace@luht.scot.nhs.uk
Current Research Projects
In Edinburgh at the Royal Hospital for Sick Children, in collaboration with the Centre for Reproductive Biology, we have an evolving established multi-disciplinary research group that has developed a track record in research into the late effects of treatment of childhood cancer.
1. Female Studies: 'Sex steroid replacement in young women with premature ovarian failure'.
2. Male Studies: 'Restoration and Protection of spermatogenesis following gonadotoxic treatment for cancer'. Our major objectives are two-fold: to further examine restoration/ protection issues for fertility preservation for young boys treated for cancer and secondly to understand more about testicular maturation, particularly during the pre-pubertal period. Background: Inexplicably, boys treated with some therapies for cancer at age 2-10 years, a time of supposed ‘testicular quiescence’, are at risk of low sperm counts/infertility in adulthood. Conclusions: These findings reinforce the view that the ‘childhood’ testis is not quiescent. This may explain the damaging effects of some cancer therapies on subsequent fertility of boys and raises the issue of protective intervention. The present studies suggest that GnRHa-based intervention might be only partially successful.
3. Bone Studies: 'Short-term growth and biochemical markers in children treated for Leukaemia and Cancer'. Funded by the Jennifer Foundation. 'Investigation of the mechanisms of the human bone cell hyperpolarisation response to cyclical mechanical strain and the effect of methotrexate and other chemotherapy agents on this system'. Funded by the Uyea Trust.
4. Cognitive Ability: 'Apolipoprotein E predicts neurodevelopmental outcome after treatment of childhood cancer'. Funded by the Melville Trust.
Important Links: United Kingdom Children's Cancer Group
Publications
1. Johnson EMM, Crofton PM, O’Neill JM, Wilkinson AG, McKenzie KJ, Munro FD, Myles L, Seckl MJ, Wallace WHB. Infantile choriocarcinoma treated with chemotherapy alone. Medical Paediatric Oncology, (2003) 41: 550-7.
2. Wallace WHB, Thomson AB, Kelsey T. The radiosensitivity of the human oocyte. Human Reproduction, (2003) 18(1):117-121.
3. Tidman MJ, Adamson B, Allan S, Wallace WHB. Childhood scabies mistaken for Langerhans cell histiocytosis. Clin Exp Dermatol, (2003) 28(1):111-2.
4. Crofton PM, Thomson AB, Evans AE, Groome NP, Bath LE, Kelnar CJ, Wallace WHB. Inhibin B as a potential marker of gonadal toxicity in prepubertal children treated for cancer. Clinical Endocrinology, (2003) 58(3):296-301.
5. Wallace WHB, Thomson AB. Preservation of fertility in children treated for cancer. Archives of Disease in Childhood (2003) 88(6):493-6.
6. Patrick KI, Wallace WHB, Critchley HOD. Late reproductive effects of cancer treatment in female survivors of childhood malignancy. Current obstetrics and gynaecology, (2003) 13:369-372.
7. SB Wharton, C Wardle, JW Ironside, Wallace WHB, JA Royds, DW Hammond. Comparative genomic hybridisation and pathological findings in atypical teratoid / rhabdoid tumour of the central nervous system. Neuropathology Applied Neurobiology, (2003) 29(3):254-261.
8. Sharpe RM, Fraser HM, Brougham MF, McKinnell C, Morris KD, Kelnar CJ, Wallace WHB, Walker M. Role of the neonatal period of pituitary - testicular activity in germ cell proliferation and differentiation in the primate testis. Human Reproduction, (2003) 18(10):2110-2117.
9. Bath LE, Wallace WHB, Shaw MP, Fitzpatrick C, Anderson RA. Depletion of the ovarian reserve in young women following treatment for cancer in childhood: detection by anti-Müllerian hormone, inhibin B and ovarian ultrasound. Human Reproduction, (2003) 18(11):2368-74.
10. Campbell J, Wallace WHB, Bhatti LA, Stockton DL, Brewster DH. (2003). Cancer in Scotland: trends in incidence, mortality, and survival 1975-1999. Edinburgh:Information and Statistics division. www.isdscotland.org/cancer_information.
11. Brougham M, Sharp RM, Kelnar CJH, Wallace WHB. Male fertility following childhood cancer: current concepts and future therapies. Asian J Androl., (2003) Dec 5 (4):325-37. 73.
12. Bath LE, Crofton PM, Evans N, Ranke MB, Elmlinger MW, Kelnar CJ, Wallace WHB. Bone turnover and growth during and after chemotherapy in children with solid tumours. Paediatric Research, (2004) 55(2) 224-30.
13. Wallace WHB, Kelsey TW. Ovarian reserve and reproductive age may be determined from measurement of ovarian volume by transvaginal sonography. Human Reproduction, (2004) 19(7) 1612-1617.
14. Taylor A, Hawkins M, Blacklay A, Davies H, Douglas C, Jenney M, Wallace WHB, Levitt G. Long-term follow up of survivors of childhood cancer in the UK. Paediatric Blood and Cancer, (2004) 42:161-168.
15. Wallace WHB, Anderson RA, Baird DT. Preservation of fertility in young women treated for cancer. Lancet Oncology, (2004) 5(5):269-70.
16. Elliot KJ, Millward-Sadler SJ, Wright MO, Robb JR, Wallace WHB, Salter DM. Effects of Methotrexate on Human Bone Cell Responses to Mechanical Stimulation. J Rheumatology, (2004) Jul 6 epub ahead of print.
17. Bath LE, Tydeman G, Critchley HOD, Anderson RA, Baird DT, Wallace WHB. Spontaneous conception in a young woman who had ovarian cortical tissue cryopreserved before chemotherapy and radiotherapy for a Ewing’s sarcoma of the pelvis. Human Reproduction, (2004), Nov;19 (11):2569-72.
18. Reynolds B, Windebank K, Leonard R, Wallace WHB. A comparison of self-reported satisfaction between adolescents treated in a “teenage” unit with those treated in adult or paediatric units. Pediatr Blood Cancer, (2005) Mar; 44 (3):259-63.
19. Stoneham S, Ashley S, Pinkerton CR, Wallace WHB, Shankar AG. Outcome after autologous hemopoietic stem cell transplantation in relapsed or refractory childhood Hodgkins disease. J Pediatr Hematol Oncol., (2004) Nov; 26 (11):740-745.
20. Wallace WHB, Anderson RA, Irvine DI. Fertility preservation for young people with cancer: who is at risk and what can be offered? Lancet Oncology, (2005); 6: 209-218.
21. Hain RDW, Miser A, Devins M, Wallace WHB. Strong opiods in paediatric palliative medicine. Paediatr Drugs. (2005);7 (1):1-9.
23 Critchley HOD and Wallace WHB. Impact of cancer treatment on uterine function. J Natl Cancer Inst., 2005 (34):64-68.
24. Critchley HOD and Wallace WHB. Radiation damage to the uterus and effects upon future pregnancy. Art and Science, (2004) 4(2):8-11.
25. Wallace WHB, Thomson AB, Saran F, Kelsey TW. Predicting age at ovarian failure following radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys., (2005) Jul 1;62 (3):738-44.
26. Wallace WHB. Ovulation induction, assisted conception and childhood cancer. Is there a link? European J Cancer, (2005) Mar; 41 (5):725-6.
27. Oeffinger KC and Wallace WHB. Barriers to follow-up care of survivors in the United States and the United Kingdom. Pediatr Blood Cancer. (2006) Feb;46 (2):135-42.
28. Landier W, Wallace WHB, Hudson MM. Long-term follow up of paediatric cancer survivors: Education, Surveillance and Screening. Pediatr Blood Cancer. (2006) Feb;46 (2):149-58.
29. Brougham MF and Wallace WHB. Subfertility in children and young people treated for solid and haematological malignancies. Br J Haematol., (2005) 131 (2):143-55.
30. Skinner R, Wallace WHB, Levitt GA. Long-term follow-up of people who have survived cancer during childhood. Lancet Oncol.2006 Jun; 7(6):489-98.
31. Mason A, Wallace AM, MacIntyre H, Teoh JP, Bath LE, Critchley HO, Kelnar CJH, Wallace WHB, Ahmed SF. Undetectable Salivary Testosterone In Young Women With Premature Ovarian Failure. Clin Endocrinol (Oxf). (2006) Jun; 64 (6):711-4.
32. Wallace WHB. Fertility Preservation for Young People Treated with Cancer: What are the Attitudes and Knowledge of Clinicians? Pediatr Blood Cancer. (2006) May 15; [Epub ahead of print].
32. Eiser C, Absolum K, Greenfield D, Glaser A, Home B, Waite H, Urquhart , Wallace WHB, Ross R, Davies H. Follow-up after childhood cancer: Evaluation of a three-level model. Eur J Cancer. (2006) Sep 19; [Epub ahead of print].
33. Wallace WHB, Anderson RA. Cancer survivors and infertility: where do we go from here? J Support Oncol. (2006) Apr;4 (4):183-4.
34. Lee SJ, Schover LR, Partiridge AH, Patrizio P, Wallace WHB, Hagerty K, Beck LN, Brennan LV, Oktay K. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol. (2006) Jun 20 ; 24 (18):2917-31.
35. Critchley HO. Wallace WHB. Do survivors of childhood cancer have increased incidence of premature menopause? Nat Clin Pract Oncol. (2007) Feb;4 (2) :84-5.
36. Skinner R, Wallace WHB, Levitt G. Long-term follow-up of children treated for cancer: why is it necessary, by whom, where and how? Arch Dis Child. (2007) Mar; 92 (3):257-60. Review.
37. Stoneham S, Ashley S, Pinkerton R, Hewitt M, Wallace WHB, Shankar AG. Children’s Cancer and Leukaemia Group. Hodgkin’s lymphoma in children aged 5 years or less - the United Kingdom experience. Eur J Cancer. Epub (2007) May 16. (2007) Jun;43 (9):1415-21.
38. Mauz-Körholz C, Gorde-Grosjean S, Hasenclever D, Shankar A, Dörffel W, Wallace WHB, Schellong G, Robert A, Korholz D, Oberlin O, Hall GW, Landman-Parker J. Resection alone in 58 children with limited stage, lymphocyte-predominant Hodgkin lymphoma-experience from the European network group on pediatric Hodgkin lymphoma. Cancer. (2007) Jul 1:10 (1):179-85.
39. Edgar AB, Wallace WHB. Pregnancy in women who had cancer in childhood. Eur J Cancer. 2007 Sep;43(13):1890-4. Epub (2007) Aug 3.
40. Hall GW, Katzilakis N, Pinkerton CR, Nicolin G, Ashley S, McCarthy K, Daw S, Hewitt M, Wallace WHB, Shankar A. Outcome of children with nodular lymphocyte predominant Hodgkin lymphoma - a Children’s Cancer and Leukaemia Group report. Br J Haematol. (2007) Sep;138(6):761-8.
41. Foster L, Dall GF, Reid R, Wallace WHB, Porter DE. Twentieth-century survival from osteosarcoma in childhood: TRENDS FROM 1933 TO 2004. J Bone Joint Surg Br. (2007) Sep;89(9):1234-8.Grants for the last five years
| 2001 - 2008 | HEBA Trust and Cancer & Leukaemia in Childhood. Virtual Centre for Research for survivors of childhood cancer. (£ 368,000). |
| 2001 - | The Jennifer Fund. Cryopreservation unit for freezing gonadal tissue. (£7000). |
| 2001 - | Pharmacia and The Child Growth Foundation. Male fertility after childhood cancer. Wallace WH. and Kelnar CJH. (£40,000). |
| 2002 - 2008 | Melville Trust. Apo E and cognitive ability after childhood cancer. Wallace WH., Johnson D, Minns RA.(£37,000). |
| 2002 | Pfizer. Studies of male reproductive function and testis morphology after treatment of childhood cancer. Wallace WH. and Kelnar CJH. (£18,500). |
| 2003 | Pfizer. Study of male reproductive function and testis morphology after treatment of childhood cancer. Wallace WH. and Kelnar CJH. (£ 27,000). |
| 2004 - 2009 | Fergus-McClay trust. Nutrition in childhood cancer. Wallace WH and Wilson D. (£98,000). |
National and International Meetings
Communications (Invited Lectures)
